Etrinabdione

In today's world, Etrinabdione has become a topic of great relevance and interest to a wide range of people. Whether it is a current topic, a prominent personality, or a relevant event, Etrinabdione arouses the curiosity and attention of individuals from different backgrounds and cultures. Its impact and relevance transcend borders and generations, making it a topic of universal relevance. In this article, we will thoroughly explore Etrinabdione and analyze its influence on the world today. Through different perspectives and evidence, we will seek to fully understand the importance and impact that Etrinabdione has on contemporary society.
Etrinabdione
Identifiers
  • 5-(benzylamino)-4-hydroxy-3--6-pentylcyclohexa-3,5-diene-1,2-dione
CAS Number
PubChem CID
Chemical and physical data
FormulaC28H35NO3
Molar mass433.592 g·mol−1
3D model (JSmol)
  • CCCCCC1=C(C(=C(C(=O)C1=O)2C=C(CC2C(=C)C)C)O)NCC3=CC=CC=C3
  • InChI=1S/C28H35NO3/c1-5-6-8-13-22-25(29-17-20-11-9-7-10-12-20)27(31)24(28(32)26(22)30)23-16-19(4)14-15-21(23)18(2)3/h7,9-12,16,21,23,29,31H,2,5-6,8,13-15,17H2,1,3-4H3/t21-,23+/m0/s1
  • Key:CGGGAXJIRQSRPH-JTHBVZDNSA-N

Etrinabdione (VCE-004.8, EHP-101) is a drug structurally related to cannabidiol and HU-331 which has potent antiinflammatory and neuroprotective effects. It acts as a dual agonist of CB2 and PPARγ and is in clinical trials for the treatment of scleroderma.

See also

References

  1. ^ Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M, Jiménez-Jiménez C, Mestre L, et al. (March 2018). "Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy". Journal of Neuroinflammation. 15 (1): 64. doi:10.1186/s12974-018-1103-y. PMC 5831753. PMID 29495967.
  2. ^ García-Martín A, Garrido-Rodríguez M, Navarrete C, Del Río C, Bellido ML, Appendino G, et al. (November 2018). "EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis". Biochemical Pharmacology. 157: 304–313. doi:10.1016/j.bcp.2018.07.047. PMID 30076848. S2CID 51921018.
  3. ^ Palomares B, Ruiz-Pino F, Navarrete C, Velasco I, Sánchez-Garrido MA, Jimenez-Jimenez C, et al. (October 2018). "VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity". Scientific Reports. 8 (1): 16092. Bibcode:2018NatSR...816092P. doi:10.1038/s41598-018-34259-0. PMC 6208444. PMID 30382123.
  4. ^ García-Martín A, Garrido-Rodríguez M, Navarrete C, Caprioglio D, Palomares B, DeMesa J, et al. (May 2019). "Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis". Biochemical Pharmacology. 163: 321–334. doi:10.1016/j.bcp.2019.02.029. PMID 30825431. S2CID 73492817.
  5. ^ Navarrete C, García-Martin A, Garrido-Rodríguez M, Mestre L, Feliú A, Guaza C, et al. (September 2020). "Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis". Neurobiology of Disease. 143: 104994. doi:10.1016/j.nbd.2020.104994. hdl:10261/219645. PMID 32599064. S2CID 220075831.
  6. ^ Burgaz S, García C, Gómez-Cañas M, Rolland A, Muñoz E, Fernández-Ruiz J (May 2021). "Neuroprotection with the Cannabidiol Quinone Derivative VCE-004.8 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson's Disease". Molecules. 26 (11): 3245. doi:10.3390/molecules26113245. PMC 8198479. PMID 34071302.
  7. ^ Caprioglio D, Mattoteia D, Taglialatela-Scafati O, Muñoz E, Appendino G (July 2021). "Cannabinoquinones: Synthesis and Biological Profile". Biomolecules. 11 (7): 991. doi:10.3390/biom11070991. PMC 8301883. PMID 34356614.
  8. ^ Navarrete C, García-Martín A, Correa-Sáez A, Prados ME, Fernández F, Pineda R, et al. (July 2022). "A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury". Journal of Neuroinflammation. 19 (1): 177. doi:10.1186/s12974-022-02540-9. PMC 9270745. PMID 35810304.
  9. ^ Lavayen BP, Yang C, Larochelle J, Liu L, Tishko RJ, de Oliveira AC, et al. (May 2023). "Neuroprotection by the cannabidiol aminoquinone VCE-004.8 in experimental ischemic stroke in mice". Neurochemistry International. 165: 105508. doi:10.1016/j.neuint.2023.105508. PMID 36863495. S2CID 257235882.
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