Fibrinoid necrosis

In this article we are going to explore the fascinating world of Fibrinoid necrosis. Whether you're a history buff, science enthusiast, fashion lover, or just someone curious by nature, Fibrinoid necrosis has something for everyone. From its impact on society to its evolution over time, this topic has left an indelible mark on the world around us. Join us on this journey as we discover the mysteries and wonders that Fibrinoid necrosis has to offer.
Micrograph showing (intensely pink) fibrinoid necrosis (large blood vessel – right of image) in a case of vasculitis (eosinophilic granulomatosis with polyangiitis). H&E stain.

Fibrinoid necrosis is a specific pattern of irreversible, uncontrolled cell death that occurs when antigen-antibody complexes are deposited in the walls of blood vessels along with fibrin. It is common in the immune-mediated vasculitides which are a result of type III hypersensitivity. When stained with hematoxylin and eosin, they appear brightly eosinophilic and smudged.

Diseases

Fibrinoid necrosis is not limited to the immune-mediated vasculitides; many pathologic processes can lead to areas of fibrinoid necrosis. In systemic lupus erythematosus, the dermis is often affected by fluid accumulation and inflammation around the small vessels in the skin, which may show prominent fibrinoid necrosis. Also it's seen in rheumatoid nodules with similar pathology. Also seen in Serum Sickness(Type III hypersensitivity reaction)

References

  1. ^ a b Robbins and Cotran pathologic basis of disease. Kumar, Vinay, Abbas, Abul K., Aster, Jon C., Perkins, James A. (Ninth ed.). Philadelphia, PA. 2014. ISBN 9781455726134. OCLC 879416939.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
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