Irampanel

In the wide universe of topics that current society addresses, Irampanel has stood out as a topic of absolute relevance. Whether due to its impact on people's daily lives, its influence in the workplace or its historical significance, Irampanel has captured the attention of a wide audience of various ages and professions. In this article, we will explore the various facets of Irampanel, from its origins to its evolution today, with the aim of providing a global perspective on this much-discussed topic.
Irampanel
Clinical data
ATC code
  • None
Identifiers
  • N,N-Dimethyl-2-ethanamine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H19N3O2
Molar mass309.369 g·mol−1
3D model (JSmol)
  • CN(C)CCOc1ccccc1c2nc(no2)c3ccccc3
  • InChI=1S/C18H19N3O2/c1-21(2)12-13-22-16-11-7-6-10-15(16)18-19-17(20-23-18)14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3
  • Key:QZULPCPLWGCGSL-UHFFFAOYSA-N

Irampanel (INN, code name BIIR-561) is a drug which acts as a dual noncompetitive antagonist of the AMPA receptor and neuronal voltage-gated sodium channel blocker. It was under development by Boehringer Ingelheim for the treatment of acute stroke/cerebral ischemia but never completed clinical trials for this indication. Irampanel was also trialed, originally, for the treatment of epilepsy and pain, but these indications, too, were abandoned, and the drug was ultimately never marketed.

References

  1. ^ a b Feigin V (June 2002). "Irampanel Boehringer Ingelheim". Current Opinion in Investigational Drugs. 3 (6): 908–910. PMID 12137411.
  2. ^ Wang KK, Larner SF, Robinson G, Hayes RL (December 2006). "Neuroprotection targets after traumatic brain injury". Current Opinion in Neurology. 19 (6): 514–519. doi:10.1097/WCO.0b013e3280102b10. PMID 17102687. S2CID 28119069.
  3. ^ Sharma SS, Kaundal RK (1 January 2007). "Targeting Molecular Pathways in Stroke". In Ray A, Gulati K (eds.). Current Trends in Pharmacology. I. K. International Pvt Ltd. pp. 321–. ISBN 978-81-88237-77-7.
  4. ^ Weiser T (April 2005). "AMPA receptor antagonists for the treatment of stroke". Current Drug Targets. CNS and Neurological Disorders. 4 (2): 153–159. doi:10.2174/1568007053544129. PMID 15857300.
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