SB-699551

In this article, the impact that SB-699551 has had on different aspects of society will be addressed. Since its emergence, SB-699551 has aroused the interest of researchers, academics, specialists and the general public, due to its relevance in various areas. The influence of SB-699551 on culture, economy, technology, politics, among other aspects, will be explored with the aim of understanding its role in shaping the current world. In addition, it will be analyzed how SB-699551 has transformed the way people interact with each other and how they operate in their environment. Through this article, we aim to provide a comprehensive view of SB-699551, allowing the reader to obtain a broader and clearer perspective on its impact and significance.
SB-699551
Identifiers
  • 3-cyclopentyl-N--N-methyl)-4-biphenylyl)methyl]propanamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC34H45N3O
Molar mass511.754 g·mol−1
3D model (JSmol)
  • C2CCCC2CCC(=O)N(CCN(C)C)Cc(cc3)ccc3-c(cc1)ccc1CNCCc4ccccc4
  • InChI=1S/C34H45N3O/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3
  • Key:SEQAMPXQRKYYQF-UHFFFAOYSA-N
  (verify)

SB-699551 is a drug which was the first compound developed to act as a selective antagonist for the serotonin receptor 5-HT5A, with selectivity of around 100x over other serotonin receptor subtypes. Multiple therapeutic roles have been suggested for 5-HT5A ligands due to the presence of this receptor in several areas of the brain, but research is still at an early stage, In animal studies, SB-699551 was found to block cue-mediated responding to LSD, again suggesting an antipsychotic type of activity. It also reduces the viability of certain types of cancer cells in vitro, suggesting the 5-HT5A receptor as a possible target for novel chemotherapy drugs.

References

  1. ^ Thomas DR, Soffin EM, Roberts C, Kew JN, de la Flor RM, Dawson LA, et al. (September 2006). "SB-699551-A (3-cyclopentyl-N--N-methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain". Neuropharmacology. 51 (3): 566–577. doi:10.1016/j.neuropharm.2006.04.019. PMID 16846620. S2CID 543423.
  2. ^ Nikiforuk A, Hołuj M, Kos T, Popik P (June 2016). "The effects of a 5-HT5A receptor antagonist in a ketamine-based rat model of cognitive dysfunction and the negative symptoms of schizophrenia". Neuropharmacology. 105: 351–360. doi:10.1016/j.neuropharm.2016.01.035. PMID 26826431. S2CID 31557477.
  3. ^ Popik P, Krawczyk M, Kuziak A, Bugno R, Hogendorf A, Staroń J, Nikiforuk A (November 2019). "Serotonin type 5A receptor antagonists inhibit D-lysergic acid diethylamide discriminatory cue in rats". Journal of Psychopharmacology. 33 (11): 1447–1455. doi:10.1177/0269881119867603. PMID 31452444. S2CID 201733534.
  4. ^ Itsumi M, Shiota M, Sekino Y, Ushijima M, Kashiwagi E, Takeuchi A, et al. (August 2020). "High-throughput screen identifies 5-HT receptor as a modulator of AR and a therapeutic target for prostate cancer". The Prostate. 80 (11): 885–894. doi:10.1002/pros.24022. PMID 32483877. S2CID 219174471.
  5. ^ Gwynne WD, Shakeel MS, Girgis-Gabardo A, Kim KH, Ford E, Dvorkin-Gheva A, et al. (August 2020). "Antagonists of the serotonin receptor 5A target human breast tumor initiating cells". BMC Cancer. 20 (1): 724. doi:10.1186/s12885-020-07193-6. PMC 7404930. PMID 32758183.
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